A Ras1‐Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans
نویسندگان
چکیده
منابع مشابه
The capsule of the fungal pathogen Cryptococcus neoformans.
The capsule of the fungal pathogen Cryptococcus neoformans has been studied extensively in recent decades and a large body of information is now available to the scientific community. Well-known aspects of the capsule include its structure, antigenic properties and its function as a virulence factor. The capsule is composed primarily of two polysaccharides, glucuronoxylomannan (GXM) and galacto...
متن کاملCharacterization of the Complete Uric Acid Degradation Pathway in the Fungal Pathogen Cryptococcus neoformans
Degradation of purines to uric acid is generally conserved among organisms, however, the end product of uric acid degradation varies from species to species depending on the presence of active catabolic enzymes. In humans, most higher primates and birds, the urate oxidase gene is non-functional and hence uric acid is not further broken down. Uric acid in human blood plasma serves as an antioxid...
متن کاملImmunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans
Vaccination and infection can elicit protective and nonprotective antibodies to the fungus Cryptococcus neoformans in mice. The effect of nonprotective antibodies on host defense is unknown. In this study we used mixtures of protective and nonprotective monoclonal antibodies (mAbs) to determine if nonprotective mAbs blocked the activity of the protective mAbs. Antibody isotype and epitope speci...
متن کاملWhat makes Cryptococcus neoformans a pathogen?
Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years because of the onset of AIDS and the expanded use of immunosuppressive drugs. Intricate host-organism interactions make the full understanding of pathogenicity and virulence of C. neoformans difficult. We discuss the current knowledge of the charact...
متن کاملThe ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans
In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under stress conditions. During temperature adaptation in the human fungal pathogen Cryptococcus neoformans, ER stress is engaged transiently. Studies of this response have demonstrated that both the engagement (turning on the response), as well as the resolution (turning off the response) are required for tem...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2006
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2006.05566.x